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KMID : 0948920160150020092
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Clinical Pain
2016 Volume.15 No. 2 p.92 ~ p.96
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Effect of Transcutaneous High Frequency Wave on the Change of Tissue Temperature and Histology in Sprague-Dawley Rat
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Kim Kyung-Ah
Moon Chang-Won
Song Da-Hyun
Kim Sang-Jun
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Abstract
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Objective: High frequency wave has been used in cancer treatment and cosmetic area but not in musculoskeletal pain yet. The purpose of this study is to evaluate temperature distribution according to depth and confirm safety of high frequency wave through animal study.
Method: High frequency wave was applied to the posterior limb of 9 Sprague-Dawley rats for 20 minutes (experimental group) and no wave was used in the same number of rats for control group. Tissue temperature was measured from skin surface to 1 cm depth (surface, 1 mm, 5 mm, and 1 cm) for 5 seconds.
Results: In the experimental group, temperature was elevated 3.2oC at skin surface, 2.87oC at 1 mm, 2.25oC in 5 mm, and 1.74oC in 1 cm depth. These were significantly different from those in the control group (p＜ 0.001). There was no bulla or redness in the skin after high frequency wave stimulation and neither change of myocytes nor collagen degeneration was found in the tissue histology. There was no apoptosis in the skin surface and muscle layer in TUNEL assay.
Conclusion: High frequency wave elevated tissue temperature from the skin to muscle layer without both histologic change and apoptosis
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KEYWORD
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High frequency, Rat, Temperature, Tissue, , Safety
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